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Frequently asked questions

Medication Guide

How does LUZ work?

 

1.      Your provider will determine if you are a candidate and send a prescription to us if so

2.      You fill out short patient questionnaire

3.      Receive your medication in 2-3 business days

 

How do I take LUZ?

 

Shake bottle well before drawing up dose in oral syringe. Place dose under the tongue and hold for at least 90 sec. Wait 30 minutes before eating or drinking. Store at room temperature/avoid excess heat. Keep out of reach of children.

 

What are the benefits of LUZ?

 

-          No injections

o   No weekly appointments save you time

o   Don’t have to worry about bruising from injections

-          Cost savings

o   Less spent on food and alcohol due to potential decreased consumption

o   Save on gas due to no weekly injection appointments

-          Convenience

o   Shipped directly to your door

 

How much weight can I expect to lose?

 

Healthy weight loss is often considered to be 1-2lbs per week. Weight loss is dependent on several factors and the most successful patients also make diet and lifestyle changes. Your healthcare provider will work with you to get you to an ideal dose for appropriate weight loss.

 

What are the most common side effects?

 

The most common side effects may include nausea, stomach (abdominal) pain, diarrhea, decreased appetite, vomiting, and constipation. Make sure to talk with your healthcare provider if you have any questions about side effects.

 

 

What can I do if I experience nausea?

 

Speak with your healthcare provider if you experience nausea or have any questions about side effects.

Here are some general nausea tips that may be helpful:

·         Eat bland, low-fat foods, like crackers, toast, and rice

·         Eat foods that contain water, like soups and gelatin

·         Avoid fried, greasy, or sweet foods

·         Avoid lying down after you eat

·         Go outdoors for fresh air

·         Eat more slowly

·         Drink clear or ice-cold drinks

 

Who can’t take LUZ?

 

-          History of anaphylaxis or angioedema to GLP-1 receptor agonists

-          <18 years old or >75 years old

-          Personal or family history of certain types of thyroid cancer, specifically thyroid C-cell tumors such as medullary thyroid carcinoma (MTC), or in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2)

-          Pregnant or breastfeeding

 

Can I take LUZ while I'm pregnant or breastfeeding?

 

It is not known if LUZ will harm your unborn baby. Women should stop taking LUZ 2 months before they plan to become pregnant. It is not known if LUZ passes into breast milk, therefore breastfeeding is not recommended during treatment with LUZ.

 

Talk to your healthcare provider if you are pregnant, plan to become pregnant, are breastfeeding or plan to breastfeed.

 

Clinical Pharmacology – Contraindications/Precautions

Caution in patients with a history of anaphylaxis or angioedema to other GLP-1 receptor agonists

Semaglutide is contraindicated in patients with a personal or family history of certain types of thyroid cancer, specifically thyroid C-cell tumors such as medullary thyroid carcinoma (MTC), or in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2

Semaglutide should not be used for the treatment of type 1 diabetes mellitus.

Hypoglycemia should be monitored for by the patient and clinician when semaglutide treatment is initiated and continued for type 2 diabetes mellitus (T2DM) and when used for weight reduction and maintenance. In clinical trials of semaglutide injection for T2DM (Ozempic), hypoglycemia was increased when semaglutide was used in combination with a sulfonylurea; patients receiving semaglutide in combination with an insulin secretagogue (e.g., sulfonylurea) or insulin may have an increased risk of hypoglycemia, including severe hypoglycemia.

If pancreatitis is suspected, discontinue semaglutide; if pancreatitis is confirmed, do not resume semaglutide. Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including semaglutide. Incretin-based therapies should be avoided in patients with prior or current pancreatitis; otherwise, there are insufficient data to recommend withholding them for weight loss due to concerns of pancreatitis.

Use semaglutide with caution in patients with known gallbladder disease or a history of cholelithiasis. If cholelithiasis or cholecystitis are suspected in a patient taking semaglutide, gallbladder studies are indicated.

During semaglutide therapy, patients with a history of diabetic retinopathy should be closely monitored. There is an increased risk for diabetic retinopathy complications in patients with a history of diabetic retinopathy at baseline compared to patients without a known history of diabetic retinopathy

Use caution during treatment with semaglutide in patients with renal impairment or end-stage renal disease (renal failure); however, no dose adjustments are needed based on renal function.

Suicidal behavior and ideation have been reported in clinical trials with other incretin mimetics indicated for weight management. Therefore, administer semaglutide with caution in patients with depression and avoid use in patients with a history of suicide attempts or active suicidal ideation; monitor patients for the emergence or worsening of depression, suicidal thoughts or behavior, and any unusual changes in moods or behaviors.

Semaglutide for the treatment of obesity or weight management should not be used during pregnancy because weight loss offers no potential benefit to a pregnant woman and may result in fetal harm due to the potential hazard of maternal weight loss to the fetus.

Semaglutide may be associated with reproductive risk and preconceptual planning is recommended; females of childbearing potential should discontinue semaglutide at least 2 months before a planned pregnancy due to the drug's long washout period.

Use injectable semaglutide with caution during lactation; oral semaglutide therapy is not recommended during breast-feeding.